Physician assistants exercise autonomy in medical decision making as determined by their supervising physician. They are educated in the medical model designed to complement physician training, rather than in the nursing model as nurse practitioners are. Physician assistants are not to be confused with medical assistants, who perform administrative and simple clinical tasks with limited college-level education in hospitals and clinics under the direct supervision of physicians, physician assistants registered nurses, or nurse practitioners.
The profession is represented in the United States by the American Academy of Physician Assistants.

